From: Ashok T. Jaisinghani <ashokjai@sancharnet.in>
Date: Mon, Jan 10, 2011 at 4:04 PM
Subject: Fw: The Dark Side of Linus Pauling's Legacy
The Dark Side of Linus Pauling's Legacy
Stephen Barrett, M.D.
Linus Pauling, Ph.D., was the only person ever to win two unshared Nobel prizes. He received these awards for chemistry in 1954 and for peace in 1962. His death stimulated many tributes to his scientific accomplishments. His impact on the health marketplace, however, was anything but laudable.
Pauling is largely responsible for the widespread misbelief that high doses of vitamin C are effective against colds and other illnesses.
In 1968, he postulated that people's needs for vitamins and other nutrients vary markedly and that to maintain good health, many people need amounts of nutrients much greater than the Recommended Dietary Allowances (RDAs). And he speculated that megadoses of certain vitamins and minerals might well be the treatment of choice for some forms of mental illness. He termed this approach "orthomolecular," meaning "right molecule." After that, he steadily expanded the list of illnesses he believed could be influenced by "orthomolecular" therapy and the number of nutrients suitable for such use. No responsible medical or nutrition scientists share these views.
Vitamin C and the Common Cold
In 1970, Pauling announced in Vitamin C and the Common Cold that taking 1,000 mg of vitamin C daily will reduce the incidence of colds by 45% for most people but that some people need much larger amounts. (The RDA for vitamin C is 60 mg.) The 1976 revision of the book, retitled Vitamin C, the Common Cold and the Flu, suggested even higher dosages. A third book, Vitamin C and Cancer (1979) claims that high doses of vitamin C may be effective against cancer. Yet another book, How to Feel Better and Live Longer (1986), stated that megadoses of vitamins "can improve your general health . . . to increase your enjoyment of life and can help in controlling heart disease, cancer, and other diseases and in slowing down the process of aging."
Pauling himself reportedly took at least 12,000 mg daily and raised the amount to 40,000 mg if symptoms of a cold appear. In 1993, after undergoing radiation therapy for prostate cancer, Pauling said that vitamin C had delayed the cancer's onset for twenty years. This was not a testable claim. He died of the disease in August 1994 at the age of 93.
Scientific fact is established when the same experiment is carried out over and over again with the same results. To test the effect of vitamin C on colds, it is necessary to compare groups which get the vitamin to similar groups which get a placebo (a dummy pill which looks like the real thing). Since the common cold is a very variable illness, proper tests must involve hundreds of people for significantly long periods of time. At least 16 well-designed, double-blind studies have shown that supplementation with vitamin C does not prevent colds and at best may slightly reduce the symptoms of a cold. Slight symptom reduction may occur as the result of an antihistamine-like effect, but whether this has practical value is a matter of dispute. Pauling's views are based on the same studies considered by other scientists, but his analyses are flawed.
The largest clinical trials, involving thousands of volunteers, were directed by Dr. Terence Anderson, professor of epidemiology at the University of Toronto. Taken together, his studies suggest that extra vitamin C may slightly reduce the severity of colds, but it is not necessary to take the high doses suggested by Pauling to achieve this result. Nor is there anything to be gained by taking vitamin C supplements year-round in the hope of preventing colds.
Another important study was reported in 1975 by scientists at the National Institutes of Health who compared vitamin C pills with a placebo before and during colds. Although the experiment was supposed to be double-blind, half the subjects were able to guess which pill they were getting. When the results were tabulated with all subjects lumped together, the vitamin group reported fewer colds per person over a nine-month period. But among the half who hadn't guessed which pill they had been taking, no difference in the incidence or severity was found. This illustrates how people who think they are doing something effective (such as taking a vitamin) can report a favorable result even when none exists.
Vitamin C and Cancer
In 1976, Pauling and Dr. Ewan Cameron, a Scottish physician, reported that a majority of one hundred "terminal" cancer patients treated with 10,000 mg of vitamin C daily survived three to four times longer than similar patients who did not receive vitamin C supplements. However, Dr. William DeWys, chief of clinical investigations at the National Cancer Institute, found that the study was poorly designed because the patient groups were not comparable. The vitamin C patients were Cameron's, while the other patients were under the care of other physicians. Cameron's patients were started on vitamin C when he labeled them "untreatable" by other methods, and their subsequent survival was compared to the survival of the "control" patients after they were labeled untreatable by their doctors. DeWys reasoned that if the two groups were comparable, the lengths of time from entry into the hospital to being labeled untreatable should be equivalent in both groups. However, he found that Cameron's patients were labeled untreatable much earlier in the course of their disease -- which means that they entered the hospital before they were as sick as the other doctors' patients and would naturally be expected to live longer.
Nevertheless, to test whether Pauling might be correct, the Mayo Clinic conducted three double-blind studies involving a total of 367 patients with advanced cancer. The studies, reported in 1979, 1983, and 1985, found that patients given 10,000 mg of vitamin C daily did no better than those given a placebo. Pauling criticized the first study, claiming that chemotherapeutic agents might have suppressed the patients' immune systems so that vitamin C couldn't work. But his 1976 report on Cameron's work states clearly that: "All patients are treated initially in a perfectly conventional way, by operation, use of radiotherapy, and the administration of hormones and cytotoxic substances." And during a subsequent talk at the University of Arizona, he stated that vitamin C therapy could be used along with all conventional modalities. The participants in the 1983 study had not undergone conventional treatment, but Pauling dismissed its results anyway.
Science aside, it is clear that Pauling was politically aligned with the promoters of unscientific nutrition practices. He said his initial interest in vitamin C was aroused by a letter from biochemist Irwin Stone, with whom he subsequently maintained a close working relationship. Although Stone was often referred to as "Dr. Stone," his only credentials were a certificate showing completion of a two-year chemistry program, an honorary chiropractic degree from the Los Angeles College of Chiropractic, and a "Ph.D." from Donsbach University, a nonaccredited correspondence school.
In a little-publicized chapter in Vitamin C and the Common Cold, Pauling attacked the health-food industry for misleading its customers. Pointing out that "synthetic" vitamin C is identical with "natural" vitamin C, he warned that higher-priced "natural" products are a "waste of money." And he added that "the words 'organically grown' are essentially meaningless -- just part of the jargon used by health-food promoters in making their excess profits, often from elderly people with low incomes." But Vitamin C, the Common Cold and the Flu, issued six years later, contained none of these criticisms. This omission was not accidental. In response to a letter, Pauling informed me that, after his first book came out, he was "strongly attacked by people who were also attacking the health-food people." His critics were so "biased," he decided, that he would no longer help them attack the health-food industry while another part of their attack was directed at him.
The Linus Pauling Institute of Medicine, founded in 1973, is dedicated to "orthomolecular medicine." The institute's largest corporate donor has been Hoffmann-La Roche, the pharmaceutical giant that produces most of the world's vitamin C. Many of the institute's fundraising brochures have contained questionable information. They have falsely claimed, for example, that no significant progress has been made in cancer treatment in the past twenty years. This viewpoint, which is frequently expressed by promoters of unproven cancer therapies, is simply untrue.
Other Questionable Activities
A dispute between Pauling and Arthur Robinson, Ph.D., gives additional evidence of Pauling's defense of vitamin C megadosage was less than honest. Robinson, a former student and long-time associate of Pauling, helped found the institute and became its first president. According to an investigative report by James Lowell, Ph.D., in Nutrition Forum newsletter, Robinson's own research led him to conclude in 1978 that the high doses (5-10 grams per day) of vitamin C being recommended by Pauling might actually promote some types of cancer in mice.
Robinson told Lowell, for example, that animals fed quantities equivalent to Pauling's recommendations contracted skin cancer almost twice as frequently as the control group and that only doses of vitamin C that were nearly lethal had any protective effect. Shortly after reporting this to Pauling, Robinson was asked to resign from the institute, his experimental animals were killed, his scientific data were impounded, and some of the previous research results were destroyed. Pauling also declared publicly that Robinson's research was "amateurish" and inadequate.
Robinson responded by suing the Institute and its trustees. In 1983, the suit was settled out of court for $575,000. In an interview quoted in Nature, Pauling said that the settlement "represented no more than compensation for loss of office and the cost of Robinson's legal fees." However, the court-approved agreement states that $425,000 of the settlement was for slander and libel.
During the mid-1970s, Pauling helped lead the health-food industry's campaign for a federal law that weakened FDA protection of consumers against misleading nutrition claims. In 1977 and 1979, Pauling received awards and presented his views on vitamin C at the annual conventions of the National Nutritional Foods Association (the major trade association of health-food retailers, distributors and producers).
In 1981, he accepted an award from the National Health Federation (NHF) for "services rendered in behalf of health freedom" and gave his daughter a life membership in this organization.
NHF promotes the gamut of quackery. Many of its leaders have been in legal difficulty and some have even received prison sentences for various "health" activities.
Pauling also spoke at a Parker School for Professional Success Seminar, a meeting where chiropractors were taught highly questionable methods of building their practices. An ad for the meeting invited chiropractors to pose with Pauling for a photograph (which presumably could be used for publicity when the chiropractors returned home).
In 1981, after learning that Pauling had donated money to NHF (for his daughter's life membership), I asked whether he knew about NHF's shady background and the fact that it was the leading antifluoridation force in the United States. I also asked whether he cared that the money might be used to help fight fluoridation. In a series of letters, he replied that he: (1) strongly supported fluoridation, (2) was aware of NHF's opposition, (3) had tried to pressure the organization to change its views, (4) had spoken out for it often and over many years, and (5) thought other issues were more important. He also sent me a profluoridation statement he had issued in 1967. His claim that he had spoken out for fluoridation surprised me. Altough I have read thousands of documents related to Paulings views and activities, I had never any indication that he had publicly supported fluoridation.
In 1983, Pauling and Irwin Stone testified at a hearing on behalf of Oscar Falconi, a vitamin promoter charged by the Postal Service with making false claims for several products. Pauling supported Falconi's contentions that vitamin C was useful not only in preventing cancer, but also in curing drug addicts and destroying both viruses and bacteria.
Pauling also testified in 1984 before the California Board of Medical Quality Assurance in defense of Michael Gerber, M.D., who was accused of improperly administering to patients. One was a 56-year-old woman with treatable cancer who -- the Board concluded -- had died as a result of Gerber's neglect while he treated her with herbs, enzymes, coffee enemas, and chelation therapy. The other patients were three-year-old twin boys with ear infections for which Gerber had prescribed 70,000 or more units of vitamin A daily and coffee enemas twice daily for several weeks. Gerber lost his license to practice medicine as a result of the hearings.
A flyer distributed in 1991 by the Linus Pauling Institute recommended daily doses of 6,000 to 18,000 mg of vitamin C, 400 to 1,600 IU of vitamin E, and 25,000 IU of vitamin A, plus various other vitamins and minerals. These dosages have no proven benefit and can cause troublesome side effects.
Although Pauling's megavitamin claims lacked the evidence needed for acceptance by the scientific community, they have been accepted by large numbers of people who lack the scientific expertise to evaluate them.
Thanks largely to Pauling's prestige, annual vitamin C sales in the United States have been in the hundreds of millions of dollars for many years. The physical damage to people he led astray cannot be measured.
Does Vitamin C Prevent Colds?
High Doses of Vtamin C Are Not Effective as a Cancer Treatment
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